Dr. Kulke joined the staff of Dana-Farber Cancer Institute (DFCI) in 1997 and is currently an Associate Professor of Medicine at Harvard Medical School. He is also the Director of the DFCI's Program in Neuroendocrine and Carcinoid Tumors.

He received an MD from the University of California, San Francisco School of Medicine in 1992. He completed a residency in internal medicine at Brigham and Women's Hospital and went on to work as a fellow in medical oncology at the Dana-Farber Cancer Institute. Dr. Kulke also holds a masters degree in medical science from Harvard Medical School.

Dr. Kulke has led numerous clinical and translational studies in patients with gastrointestinal malignancies and neuroendocrine tumors. He has served as study chair for a national study of pancreatic cancer therapies performed by the Cancer and Leukemia group B and funded by the National Cancer Institute. His current efforts have focused on clinical and translational research in carcinoid and pancreatic neuroendocrine tumors. Dr. Kulke is the recipient of the George Canellos Award for Clinical Investigation and the Ruth Brufsky Award for Pancreatic Cancer Research. Dr. Kulke is the Immediate Past Chair of the NANETS Board of Directors. He is also chair of the Neuroendocrine Tumor Task Force for the National Cancer Institute and also serves on the advisory board for the European Neuroendocrine Tumor Society.